Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis

Yong Xia; Yan Liu; Chao Yang; Diane M. Simeone; Tung-Tien Sun; David J. DeGraff; Moon-shong Tang; Yingkai Zhang; Xue-Ru Wu

doi:10.1038/s41467-021-22327-5

Nature Communications (Apr 2021)

Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis

Yong Xia,
Yan Liu,
Chao Yang,
Diane M. Simeone,
Tung-Tien Sun,
David J. DeGraff,
Moon-shong Tang,
Yingkai Zhang,
Xue-Ru Wu

Affiliations

Yong Xia: Department of Urology, New York University School of Medicine
Yan Liu: Department of Urology, New York University School of Medicine
Chao Yang: Department of Chemistry, New York University
Diane M. Simeone: Department of Surgery, New York University School of Medicine
Tung-Tien Sun: Department of Cell Biology, New York University School of Medicine
David J. DeGraff: Department of Pathology and Laboratory Medicine and Department of Surgery, Division of Urology, The Pennsylvania State University College of Medicine
Moon-shong Tang: Department of Environmental Medicine, New York University School of Medicine
Yingkai Zhang: Department of Chemistry, New York University
Xue-Ru Wu: Department of Urology, New York University School of Medicine

DOI: https://doi.org/10.1038/s41467-021-22327-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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The human chromosome locus 9p21.3 is a tumour suppressor hub which encodes three CDK inhibitors, p15INK4B, p14ARF and p16INK4A. Here, the authors show that p15INK4B inhibits the cell cycle and glycolysis in a murine model of HRas + ‐mediated urothelial carcinoma and has a more relevant role as a tumour suppressor than its neighbouring p16INK4A.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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