The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia

Z. Takki Chebihi; A. Belkhayat; E. Chadli; L. Hessissen; M. El Khorassani; M. El Kababri; A. Kili; M. Khattab; Y. Bakri; N. Dakka

Leukemia Research Reports (Jan 2019)

The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia

Z. Takki Chebihi,
A. Belkhayat,
E. Chadli,
L. Hessissen,
M. El Khorassani,
M. El Kababri,
A. Kili,
M. Khattab,
Y. Bakri,
N. Dakka

Affiliations

Z. Takki Chebihi: Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University, Rabat, Morocco; BIOLAB Laboratory, Rabat, Morocco; Corresponding author at: Mohammed V University, rue Beyrouth - Imm ES, SAADA - N°401 - Rabat, Rabat 10000, Morocco.
A. Belkhayat: BIOLAB Laboratory, Rabat, Morocco
E. Chadli: BIOLAB Laboratory, Rabat, Morocco
L. Hessissen: Department of Pediatric Hemato-Oncology, Children's Hospital of Rabat, Morocco
M. El Khorassani: Department of Pediatric Hemato-Oncology, Children's Hospital of Rabat, Morocco
M. El Kababri: Department of Pediatric Hemato-Oncology, Children's Hospital of Rabat, Morocco
A. Kili: Department of Pediatric Hemato-Oncology, Children's Hospital of Rabat, Morocco
M. Khattab: Department of Pediatric Hemato-Oncology, Children's Hospital of Rabat, Morocco
Y. Bakri: Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University, Rabat, Morocco
N. Dakka: Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University, Rabat, Morocco

Journal volume & issue: Vol. 11
pp. 1 – 4

Abstract

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Cytogenetic studies of acute lymphoblastic leukemia have been at the forefront of research in the pathogenesis of cancer. The presence of recurring chromosomal abnormalities (either numeral or structural rearrangements) provides immediate clues to the genetic events leading to leukemia and many abnormalities have important prognostic significance. The rare translocation t(14,21)(q11.2;q22) has been described in pediatric T lineage ALL in only one case so far in 2000. The present study is a case report of an ALL case in which we found a t(14,21)(q11.2;q22) as a non random chromosomal abnormality among 70 analyzed pediatric ALL cases referred exclusively to BIOLAB Laboratory from the children hospital of Morocco. Keywords: Acute lymphoblastic leukemia, T(14;21), Cytogenetic abnormalities, Children, Morocco

Published in Leukemia Research Reports

ISSN: 2213-0489 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/leukemia-research-reports/

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