Individual functional interhemispheric asymmetry profile and clinical and neurophysiological features in patients with Parkinson's disease

Abstract

The authors determined the individual profile of functional interhemispheric asymmetry (IPFIA) in 70 patients (28 men and 42 women) with Parkinson's disease (PD), by using the examination protocol comprising 48 assignments, its association with clinical asymmetry and effect on electroencephalography (ECG) readings. Right-sided PD onset was significantly more frequently observed in patients with a right IPFIA than in those with mixed and left IPFIAs (p<0.05). Left-sided PD onset was significantly more common in patients with mixed and left IPFIAs than in those with a right IPFIA (p<0.05). EEG showed that the generator of pathological slow wave activity was on the side contralateral to that of the affected extremity and had a clearer lateralization in the initial involvement of the dominant hemisphere in the pathological process.

Keywords

• parkinson's disease
• individual functional interhemispheric asymmetry profile
• clinical asymmetry
• electroencephalographic study