Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata
Concetta Imperatore,
Maria Senese,
Anna Aiello,
Paolo Luciano,
Stefano Fiorucci,
Claudio D’Amore,
Adriana Carino,
Marialuisa Menna
Affiliations
Concetta Imperatore
The NeaNat Group, Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, Napoli 80131, Italy
Maria Senese
The NeaNat Group, Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, Napoli 80131, Italy
Anna Aiello
The NeaNat Group, Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, Napoli 80131, Italy
Paolo Luciano
The NeaNat Group, Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, Napoli 80131, Italy
Stefano Fiorucci
Department of Surgical and Biomedical Sciences, Faculty of Medicine, University of Perugia, Via Gambuli 1, S. Andrea delle Fratte, Perugia 06132, Italy
Claudio D’Amore
Department of Surgical and Biomedical Sciences, Faculty of Medicine, University of Perugia, Via Gambuli 1, S. Andrea delle Fratte, Perugia 06132, Italy
Adriana Carino
Department of Surgical and Biomedical Sciences, Faculty of Medicine, University of Perugia, Via Gambuli 1, S. Andrea delle Fratte, Perugia 06132, Italy
Marialuisa Menna
The NeaNat Group, Department of Pharmacy, University of Naples “Federico II”, Via D. Montesano 49, Napoli 80131, Italy
A new sulfated sterol, phallusiasterol C (1), has been isolated from the Mediterranean ascidian Phallusia fumigata and its structure has been determined on the basis of extensive spectroscopic (mainly 2D NMR) analysis. The possible role in regulating the pregnane X receptor (PXR) activity of phallusiasterol C has been investigated; although the new sterol resulted inactive, this study adds more items to the knowledge of the structure-PXR regulating activity relationships in the case of sulfated steroids.
