Nature Communications (Dec 2020)

TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage

  • Changwei Yu,
  • Nevena Cvetesic,
  • Vincent Hisler,
  • Kapil Gupta,
  • Tao Ye,
  • Emese Gazdag,
  • Luc Negroni,
  • Petra Hajkova,
  • Imre Berger,
  • Boris Lenhard,
  • Ferenc Müller,
  • Stéphane D. Vincent,
  • László Tora

DOI
https://doi.org/10.1038/s41467-020-20239-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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The vertebrate TATA-binding protein (TBP) paralogue (TBPL2) is only expressed in growing oocytes, where TBP is absent. Here the authors highlight a unique role for the TBPL2/TFIIA complex in the establishment of the oocyte transcriptome by using a specific TSS recognition code.