Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys

Brandon F. Keele; Wenjun Li; Erica N. Borducchi; Joseph P. Nkolola; Peter Abbink; Bing Chen; Michael S. Seaman; Dan H. Barouch

doi:10.1038/ncomms15740

Nature Communications (Jun 2017)

Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys

Brandon F. Keele,
Wenjun Li,
Erica N. Borducchi,
Joseph P. Nkolola,
Peter Abbink,
Bing Chen,
Michael S. Seaman,
Dan H. Barouch

Affiliations

Brandon F. Keele: AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research
Wenjun Li: Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School
Erica N. Borducchi: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
Joseph P. Nkolola: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
Peter Abbink: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
Bing Chen: Children’s Hospital
Michael S. Seaman: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
Dan H. Barouch: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center

DOI: https://doi.org/10.1038/ncomms15740
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

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Protection from neutralization-resistant SIV variants is particularly difficult to achieve by vaccination. Here, Keeleet al. use sieve analysis and show that TRIM5a restrictive rhesus monkeys are protected from neutralization-resistant SIVsmE660 variants by an adenovirus prime, env protein boost vaccine.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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