Frontiers in Endocrinology (Nov 2024)

Quantitative and qualitative assessment of a pituitary neuroendocrine tumor’s T2-signal intensity in acromegaly – a call for unification

  • Magdalena Godlewska-Nowak,
  • Magdalena Godlewska-Nowak,
  • Anna Grochowska,
  • Grzegorz Zieliński,
  • Anna Bogusławska,
  • Dariusz Adamek,
  • Maria Maksymowicz,
  • Alicja Hubalewska-Dydejczyk,
  • Aleksandra Gilis-Januszewska

DOI
https://doi.org/10.3389/fendo.2024.1441745
Journal volume & issue
Vol. 15

Abstract

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IntroductionThe T2-signal intensity (SI) of somatotroph pituitary neuroendocrine tumors (sPitNET) is associated with treatment response and granulation pattern. Our aim was to evaluate SI assessment methods and their clinical implications, including responsiveness to preoperative first-generation somatostatin analogs (SSA).MethodsThis single-center, observational study included unselected, consecutive patients with newly diagnosed acromegaly. Out of 109 treatment-naïve patients, 69 were eligible. The qualitative Visual Method involved a visual comparison of the sPitNET with the temporal gray matter. The Three Tissue Method compared the quantified SI of the sPitNET, temporal white matter, and gray matter. The signal intensity ratio of the sPitNET vs. gray matter (GM-SIR) was calculated. Tumors were divided into three groups: hyperintense (HYPER), isointense (ISO), and hypointense (HYPO) according to the Visual Method, Three Tissue Method, and GM-SIR. These groups were compared in terms of demographic, radiological, and biochemical features. The SI assessment methods were investigated for their ability to predict preoperative SSA responsiveness.ResultsSI assessment methods classified SI type correspondingly in 58-75.4% of cases. ISO constituted 39-49% of the analyzed sPitNETs. All methods identified significant differences in tumor volume between the SI groups, with HYPO being more biochemically active per tumor volume unit. According to the Three Tissue Method, patients with ISO had the youngest age at diagnosis and onset. According to the Visual Method, ISO had a lower chance of achieving insulin-like growth factor 1 (IGF1) normalization compared to HYPO (odds ratio (OR) 0.089, confidence interval (CI) 0.015-0.538, p= 0.008)), with no differences between HYPER and HYPO. Only the Visual Method predicted the IGF1 normalization after SSA. HYPER and ISO sPitNETs were classified in electron microscopy as both densely and sparsely granulated. Bihormonal tumors presented only as HYPO and ISO. According to the Three Tissue Method, no HYPO was diagnosed with sparse granulation.DiscussionWe demonstrated discrepancies between the SI assessment methods. The Visual Method predicted the outcome of preoperative treatment with SSA. Clinically, ISO behaved similarly to HYPER. Further studies are needed to unify SI assessment and improve its clinical applicability in acromegaly.

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