Initiating polyketide biosynthesis by on-line methyl esterification

Pengwei Li; Meng Chen; Wei Tang; Zhengyan Guo; Yuwei Zhang; Min Wang; Geoff P. Horsman; Jin Zhong; Zhaoxin Lu; Yihua Chen

doi:10.1038/s41467-021-24846-7

Nature Communications (Jul 2021)

Initiating polyketide biosynthesis by on-line methyl esterification

Pengwei Li,
Meng Chen,
Wei Tang,
Zhengyan Guo,
Yuwei Zhang,
Min Wang,
Geoff P. Horsman,
Jin Zhong,
Zhaoxin Lu,
Yihua Chen

Affiliations

Pengwei Li: State Key Laboratory of Microbial Resources & CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences
Meng Chen: State Key Laboratory of Microbial Resources & CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences
Wei Tang: State Key Laboratory of Microbial Resources & CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences
Zhengyan Guo: State Key Laboratory of Microbial Resources & CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences
Yuwei Zhang: State Key Laboratory of Microbial Resources & CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences
Min Wang: State Key Laboratory of Microbial Resources & CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences
Geoff P. Horsman: Department of Chemistry and Biochemistry, Wilfrid Laurier University
Jin Zhong: State Key Laboratory of Microbial Resources & CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences
Zhaoxin Lu: College of Food Science and Technology, Nanjing Agriculture University
Yihua Chen: State Key Laboratory of Microbial Resources & CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-021-24846-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Aurantinins are polyketides with unusual connectivities and broad antibacterial activity. Here the authors show the biosynthesis of aurantinins, which proceeds via an on-line methyl esterification at the terminus that enables the iterative chain elongations prior to condensation and cyclization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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