In Silico Design of E3 Ubiquitin-Protein Ligase NEDD4-1 Inhibitors: An Alternative Approach for Targeting the MAPK Pathway in Cancer Therapy

Davide Pirolli; Benedetta Righino; Beatrice Tropea; Fiorella Gurrieri; Eugenio Sangiorgi; Maria Cristina De Rosa

doi:10.3390/proceedings2019022010

Proceedings (Aug 2019)

In Silico Design of E3 Ubiquitin-Protein Ligase NEDD4-1 Inhibitors: An Alternative Approach for Targeting the MAPK Pathway in Cancer Therapy

Davide Pirolli,
Benedetta Righino,
Beatrice Tropea,
Fiorella Gurrieri,
Eugenio Sangiorgi,
Maria Cristina De Rosa

Affiliations

Davide Pirolli: Institute of Chemistry of Molecular Recognition (National Research Council), 00168 Rome, Italy
Benedetta Righino: Institute of Biochemistry and Clinical Biochemistry, Catholic University of Rome, 00168 Rome, Italy
Beatrice Tropea: Sapienza University of Rome, 00100 Rome, Italy
Fiorella Gurrieri: Institute of Genomic Medicine, Catholic University of Rome, 00168 Rome, Italy
Eugenio Sangiorgi: Institute of Genomic Medicine, Catholic University of Rome, 00168 Rome, Italy
Maria Cristina De Rosa: Institute of Chemistry of Molecular Recognition (National Research Council), 00168 Rome, Italy

DOI: https://doi.org/10.3390/proceedings2019022010
Journal volume & issue: Vol. 22, no. 1
p. 10

Abstract

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Among all the several targets in common use in the antitumor therapies, the pharmacologicinhibition of the MAPK (Mitogen Activated Protein Kinase) pathway represents an efficienttherapeutic approach [1]. [...]

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Published in Proceedings

ISSN: 2504-3900 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: General Works
Website: http://www.mdpi.com/journal/proceedings

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