Synergistic interaction between anti-allergic drug and cationic/anionic surfactants–Experimental and theoretical analysis

Abstract

To search a new drug delivery excipient, this effort deals with the effects of cationic (hexadecyltrimethylammonium bromide, CTAB) and anionic (sodium dodecylbenzene sulfonate, SDBS) surfactants on the physicochemical properties of the anti-allergic drug (diphenhydramine hydrochloride, DPH). The tensiometric study has been done to find the nature of the interaction between drug and ionic surfactants. Numerous micellar, surface and conforming energetic parameters have been intended from this technique. Several physical models (Clint, Rubingh, Rosen, and Motomura) based on pseudo-phase approximation and regular solution theory, have been applied to compute these meaningful physical parameters. The DPH is a positively charged amphiphilic drug, while CTAB and SDBS are positively and negatively charged surfactants. It is experienced stronger attractive interaction of DPH with SDBS as compared to CTAB.

Keywords

• Anti-allergic drug
• Cationic surfactant
• Anionic surfactant
• Mixed micelle
• Synergism