Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment

Abstract

Tau, an intrinsically disordered axonal protein, binds to and regulates microtubule dynamics. Here, the authors use SAXS and electron microscopy to examine the architectures of microtubule bundles, including those mimicking microtubule fascicles in the axon initial segment.