Детские инфекции (Москва) (Sep 2018)
FEATURES OF THE FORMATION OF INTESTINAL MICROBIOTA AT THE STAGE OF INTRAUTERINE DEVELOPMENT OF THE FETUS
Abstract
Purpose: to study the features of the parietal intestinal microbiota of pregnant women at risk of intrauterine infection and their effect on the mother-placenta-fetus system and the formation of infant health.Materials and methods. 20 mother-child pairs of a risk group for intrauterine infection with an assessment in mothers: the course of previous pregnancies, the presence of infectious and inflammatory diseases of the pelvic organs, as well as monitoring of the current course of pregnancy, childbirth, the postpartum period and the course of the neonatal period were performed. in their infants: the presence of perinatal infections-cytomegalovirus infection and neonatal herpes, transferred to ARVI, the nature of feeding. All women for 34—37 weeks of gestation and their infants in 15—30 days of life to evaluate the species and quantity composition of the parietal intestinal microbiota used the method of gas chromatography-mass spectrometry with the determination of the concentration of microbial markers (fatty acids of the cell wall of microorganisms) by drop of blood, concentration which is identical to that of the parietal microbiota of the intestine.Results: In all women, an excessive number of microbial markers, predominantly of the Firmicutes type: Anaerobes, Aerobic Actinomycetes, Cocci, Bacilli and some species of microscopic Fungi, were detected in the deficit of priority genera (Bifidobacterium spp., Lactobacillus spp., Eubacterium spp., Propionibacterium), which led to a decrease in the plasmalogen level to 12—39 μmol / L (norm 50) and the excess of endotoxin to 1.5 nanomol / ml (normal 0.5), as well as the excess of the reference values of the markers of the herpes viruses by 3 or more times and their associations.Conclusion: violations of parietal intestinal microbiota of pregnant women and their negative impact on the «mother-placenta-fetus» system and the formation of infant health have been established.
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