Nature Communications (Mar 2020)
Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease
- F. J. Ryan,
- A. M. Ahern,
- R. S. Fitzgerald,
- E. J. Laserna-Mendieta,
- E. M. Power,
- A. G. Clooney,
- K. W. O’Donoghue,
- P. J. McMurdie,
- S. Iwai,
- A. Crits-Christoph,
- D. Sheehan,
- C. Moran,
- B. Flemer,
- A. L. Zomer,
- A. Fanning,
- J. O’Callaghan,
- J. Walton,
- A. Temko,
- W. Stack,
- L. Jackson,
- S. A. Joyce,
- S. Melgar,
- T. Z. DeSantis,
- J. T. Bell,
- F. Shanahan,
- M. J. Claesson
Affiliations
- F. J. Ryan
- School of Microbiology, University College Cork
- A. M. Ahern
- School of Microbiology, University College Cork
- R. S. Fitzgerald
- School of Microbiology, University College Cork
- E. J. Laserna-Mendieta
- School of Microbiology, University College Cork
- E. M. Power
- School of Microbiology, University College Cork
- A. G. Clooney
- School of Microbiology, University College Cork
- K. W. O’Donoghue
- School of Microbiology, University College Cork
- P. J. McMurdie
- Second Genome
- S. Iwai
- Second Genome
- A. Crits-Christoph
- Second Genome
- D. Sheehan
- APC Microbiome Ireland, University College Cork
- C. Moran
- APC Microbiome Ireland, University College Cork
- B. Flemer
- School of Microbiology, University College Cork
- A. L. Zomer
- Radboud University Medical Center, Laboratory of Pediatric Infectious Diseases
- A. Fanning
- APC Microbiome Ireland, University College Cork
- J. O’Callaghan
- School of Microbiology, University College Cork
- J. Walton
- School of Food and Nutritional Sciences, University College Cork
- A. Temko
- Irish Centre for Fetal and Neonatal Translational Research, Department of Electrical and Electronic Engineering, University College Cork
- W. Stack
- Bon Secours Hospital
- L. Jackson
- Bon Secours Hospital
- S. A. Joyce
- APC Microbiome Ireland, University College Cork
- S. Melgar
- APC Microbiome Ireland, University College Cork
- T. Z. DeSantis
- Second Genome
- J. T. Bell
- Department of Twin Research and Genetic Epidemiology, King’s College London
- F. Shanahan
- APC Microbiome Ireland, University College Cork
- M. J. Claesson
- School of Microbiology, University College Cork
- DOI
- https://doi.org/10.1038/s41467-020-15342-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Inflammatory bowel disease (IBD) has been linked to host-microbiota interactions. Here, the authors investigate mucosa-associated microbiota using endoscopically-targeted biopsies from inflamed and non-inflamed colon in patients with Crohn’s disease and ulcerative colitis, finding associations with inflammation and host epigenomic alterations.
