Variability of thyroid hormones in newborns from mothers with endemic goiter

Abstract

Background: The study of thyroid status and its influence on neonatal and postneonatal development of newborns from mothers with endemic goiter (EG) is one of the topical areas of modern endocrinology. Objective: The study of thyroid hormone levels in newborns born to women with endemic goiter. Materials and Methods: The design of the study is based on a randomized controlled method, taking into account the requirements of CONSORT, with distribution into mutually comparable study groups. A study was carried out on 68 newborns born to women with EG. Methods included the collection of history and study of thyroid hormone levels in neonates and women in labor. Results: In newborns born from women with EG, thyroid-stimulating hormone (TSH) in cord blood averaged 15.6 ± 0.87 mIU/l, which is 22.38% higher compared to the control group (P = 0.038). The difference between free triiodothyronine (T3) and thyroxine (T4) in newborns from mothers with EG in comparison to the control group was below 8.57% and 4.29%, respectively. In the 1st month of life, a lag in weight gain was noted by an average of 9.57% concerning practically healthy newborns. Conclusions: In newborns from women with EG, there was a decrease in T4 – 4.29% and T3 – 8.57%, against the background of an increase in the level of TSH to 22.38% in the cord blood relative to children from the control group. These fluctuations may persist in the 1st month of life and manifest as a delay in weight gain.

Keywords

• newborns
• thyroid
• thyroid-stimulating hormone
• thyroxine
• triiodothyronine