Nature Communications (Mar 2021)

Bi-directional regulation of cognitive control by distinct prefrontal cortical output neurons to thalamus and striatum

  • Sybren F. de Kloet,
  • Bastiaan Bruinsma,
  • Huub Terra,
  • Tim S. Heistek,
  • Emma M. J. Passchier,
  • Alexandra R. van den Berg,
  • Antonio Luchicchi,
  • Rogier Min,
  • Tommy Pattij,
  • Huibert D. Mansvelder

DOI
https://doi.org/10.1038/s41467-021-22260-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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This study presents an anatomical, neurophysiological and functional characterization of four distinct prefrontal populations that project to striatal and thalamic sub-regions. The authors show that each of these populations have a discrete role in the regulation of cognitive control.