Nature Communications (Jul 2017)

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

  • Adonia E. Papathanassiu,
  • Jeong-Hun Ko,
  • Martha Imprialou,
  • Marta Bagnati,
  • Prashant K. Srivastava,
  • Hong A. Vu,
  • Danilo Cucchi,
  • Stephen P. McAdoo,
  • Elitsa A. Ananieva,
  • Claudio Mauro,
  • Jacques Behmoaras

DOI
https://doi.org/10.1038/ncomms16040
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

BCATs catabolize leucine and other BCAAs. Here the authors show that BCAA metabolism affects the broken Krebs cycle, reprogramming macrophages to be less proinflammatory, and show that BCAT1 inhibitor ERG240 can treat arthritis in mice and glomerulonephritis in rats.