Nature Communications (Aug 2017)
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells
- Satish Ranjan,
- Alexander Goihl,
- Shrey Kohli,
- Ihsan Gadi,
- Mandy Pierau,
- Khurrum Shahzad,
- Dheerendra Gupta,
- Fabian Bock,
- Hongjie Wang,
- Haroon Shaikh,
- Thilo Kähne,
- Dirk Reinhold,
- Ute Bank,
- Ana C. Zenclussen,
- Jana Niemz,
- Tina M. Schnöder,
- Monika Brunner-Weinzierl,
- Thomas Fischer,
- Thomas Kalinski,
- Burkhart Schraven,
- Thomas Luft,
- Jochen Huehn,
- Michael Naumann,
- Florian H. Heidel,
- Berend Isermann
Affiliations
- Satish Ranjan
- Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke- University Magdeburg
- Alexander Goihl
- Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University Magdeburg
- Shrey Kohli
- Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke- University Magdeburg
- Ihsan Gadi
- Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke- University Magdeburg
- Mandy Pierau
- Department of Experimental Pediatrics, Otto-von-Guericke-University Magdeburg
- Khurrum Shahzad
- Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke- University Magdeburg
- Dheerendra Gupta
- Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke- University Magdeburg
- Fabian Bock
- Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke- University Magdeburg
- Hongjie Wang
- Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke- University Magdeburg
- Haroon Shaikh
- Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke- University Magdeburg
- Thilo Kähne
- Institute of Experimental Internal Medicine, Center of Internal Medicine, Otto-von-Guericke University Magdeburg
- Dirk Reinhold
- Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University Magdeburg
- Ute Bank
- Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University Magdeburg
- Ana C. Zenclussen
- Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University
- Jana Niemz
- Department of Experimental Immunology, Helmholtz Centre for Infection Research (HZI)
- Tina M. Schnöder
- Internal Medicine II, Hematology and Oncology, University Hospital Jena
- Monika Brunner-Weinzierl
- Department of Experimental Pediatrics, Otto-von-Guericke-University Magdeburg
- Thomas Fischer
- Department of Hematology and Oncology, Center of Internal Medicine, Otto-von-Guericke University Magdeburg
- Thomas Kalinski
- Institute for Pathology, Otto-von-Guericke University Magdeburg
- Burkhart Schraven
- Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University Magdeburg
- Thomas Luft
- Department of Medicine V, University of Heidelberg
- Jochen Huehn
- Department of Experimental Immunology, Helmholtz Centre for Infection Research (HZI)
- Michael Naumann
- Institute of Experimental Internal Medicine, Center of Internal Medicine, Otto-von-Guericke University Magdeburg
- Florian H. Heidel
- Internal Medicine II, Hematology and Oncology, University Hospital Jena
- Berend Isermann
- Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke- University Magdeburg
- DOI
- https://doi.org/10.1038/s41467-017-00169-4
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand Treg cells, mitigating the disease in mice.
