Frontiers in Endocrinology (Aug 2017)

Albuminuria Reduction after High Dose of Vitamin D in Patients with Type 1 Diabetes Mellitus: A Pilot Study

  • João Soares Felício,
  • Alana Ferreira de Oliveira,
  • Amanda Soares Peixoto,
  • Ana Carolina Contente Braga de Souza,
  • João Felício Abrahão Neto,
  • Franciane Trindade Cunha de Melo,
  • Carolina Tavares Carvalho,
  • Manuela Nascimento de Lemos,
  • Sávio Diego Nascimento Cavalcante,
  • Fabricio de Souza Resende,
  • Márcia Costa dos Santos,
  • Ana Regina Motta,
  • Luísa Corrêa Janaú,
  • Elizabeth Sumi Yamada,
  • Karem Miléo Felício

DOI
https://doi.org/10.3389/fendo.2017.00199
Journal volume & issue
Vol. 8

Abstract

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BackgroundSome studies suggest an association between diabetic kidney disease (DKD) and vitamin D (VD), but there is no data about the effect of high dose of VD on DKD in type 1 diabetes mellitus (T1DM). Our pilot study aims to evaluate albuminuria reduction in patients with T1DM supplemented with high dose of VD.Methods22 patients received doses of 4,000 and 10,000 IU/day of cholecalciferol for 12 weeks according to patient’s previous VD levels. They were submitted to continuous glucose monitoring system, 24 hours ambulatory blood pressure monitoring and urine albumin-to-creatinine ratio before and after VD supplementation.ResultsThere was a reduction of DKD prevalence at the end of the study (68 vs 32%; p = 0.05), with no changes on insulin doses, glycated hemoglobin, glycemic variability and blood pressure values. A correlation between percentage variation of VD levels (ΔVD) and albuminuria at the end of the study was presented (r = −0.5; p < 0.05). Among T1DM patients with DKD at the beginning of the study, 8/13 (62%) had their DKD stage improved, while the other five ones (38%) showed no changes (p < 0.05).ConclusionOur pilot study suggests an association between VD high dose supplementation, lower prevalence and improvement in stages of DKD in T1DM.

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