Nature Communications (May 2020)
TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination
- Meng Deng,
- Jason W. Tam,
- Lufei Wang,
- Kaixin Liang,
- Sirui Li,
- Lu Zhang,
- Haitao Guo,
- Xiaobo Luo,
- Yang Zhang,
- Alex Petrucelli,
- Beckley K. Davis,
- Brian J. Conti,
- W. June Brickey,
- Ching-Chang Ko,
- Yu L. Lei,
- Shaocong Sun,
- Jenny P. -Y. Ting
Affiliations
- Meng Deng
- Oral and Craniofacial Biomedicine PhD Program, University of North Carolina at Chapel Hill
- Jason W. Tam
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Lufei Wang
- Oral and Craniofacial Biomedicine PhD Program, University of North Carolina at Chapel Hill
- Kaixin Liang
- Oral and Craniofacial Biomedicine PhD Program, University of North Carolina at Chapel Hill
- Sirui Li
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Lu Zhang
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Haitao Guo
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Xiaobo Luo
- Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, University of Michigan Rogel Cancer Center, University of Michigan
- Yang Zhang
- Department of Dermatology, the Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University
- Alex Petrucelli
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Beckley K. Davis
- Department of Biology, Franklin and Marshall College
- Brian J. Conti
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- W. June Brickey
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Ching-Chang Ko
- Oral and Craniofacial Biomedicine PhD Program, University of North Carolina at Chapel Hill
- Yu L. Lei
- Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, University of Michigan Rogel Cancer Center, University of Michigan
- Shaocong Sun
- Department of Immunology, The University of Texas MD Anderson Cancer Center
- Jenny P. -Y. Ting
- Oral and Craniofacial Biomedicine PhD Program, University of North Carolina at Chapel Hill
- DOI
- https://doi.org/10.1038/s41467-020-16014-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
RNA viruses can be detected by immune cell pattern recognition receptors, such as RLRs, resulting in MAVS-TBK1-IRF3 signalling and production of antiviral type 1 interferons. Here the authors show that macrophage TRAF3-interacting protein 3 regulates this signalling pathway by interacting with TRAF3 and TBK1 to suppress interferon responses.
