Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases

Tong Zhao; Yuchen Zhu; Rui Zhao; Shiyi Xiong; Jing Sun; Juntao Zhang; Daidi Fan; Jianjun Deng; Haixia Yang

Pharmacological Research (Jul 2023)

Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases

Tong Zhao,
Yuchen Zhu,
Rui Zhao,
Shiyi Xiong,
Jing Sun,
Juntao Zhang,
Daidi Fan,
Jianjun Deng,
Haixia Yang

Affiliations

Tong Zhao: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Yuchen Zhu: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Rui Zhao: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Shiyi Xiong: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Jing Sun: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Juntao Zhang: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Daidi Fan: Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Biotech & Biomed Research Institute, School of Chemical Engineering, Northwest University, Xi’an, China
Jianjun Deng: State Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China; Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, Biotech & Biomed Research Institute, School of Chemical Engineering, Northwest University, Xi’an, China; Corresponding author at: State Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Haixia Yang: College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Corresponding author.

Journal volume & issue: Vol. 193
p. 106820

Abstract

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Nuciferine aporphine alkaloid mainly exists in Nelumbo nucifera Gaertn and is a beneficial to human health, such as anti-obesity, lowering blood lipid, prevention of diabetes and cancer, closely associated with inflammation. Importantly, nuciferine may contribute to its bioactivities by exerting intense anti-inflammatory activities in multiple models. However, no review has summarized the anti-inflammatory effect of nuciferine. This review critically summarized the information regarding the structure-activity relationships of dietary nuciferine. Moreover, biological activities and clinical application on inflammation-related diseases, such as obesity, diabetes, liver, cardiovascular diseases, and cancer, as well as their potential mechanisms, involving oxidative stress, metabolic signaling, and gut microbiota has been reviewed. The current work provides a better understanding of the anti-inflammation properties of nuciferine against multiple diseases, thereby improving the utilization and application of nuciferine-containing plants across functional food and medicine.

Published in Pharmacological Research

ISSN: 1096-1186 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.sciencedirect.com/journal/pharmacological-research

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Abstract

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