Frontiers in Pediatrics (Feb 2023)

Platelet and ferritin as early predictive factors for the development of macrophage activation syndrome in children with Kawasaki disease: A retrospective case-control study

  • Hua-yong Zhang,
  • Min Xiao,
  • Dan Zhou,
  • Fan Yan,
  • Yong Zhang

DOI
https://doi.org/10.3389/fped.2023.1088525
Journal volume & issue
Vol. 11

Abstract

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ObjectiveTo investigate the early predictive factors for Kawasaki disease complicated with macrophage activation syndrome (KD-MAS)MethodsWe performed a retrospective case-control study in children with KD from August 2017 to August 2022, involving 28 cases with KD-MAS and 112 cases not developing KD-MAS. Based on the univariate analysis, binary logistic regression was used to identify the early predictive factors for KD-MAS development, and the receiver operating characteristic curve (ROC) analysis was carried out to obtain the optimal cut-off value.ResultsTwo predictive factors were associated with the development of KD-MAS, which were PLT (OR = 1.013, 95%CI, 1.001–1.026), and serum ferritin (OR = 0.991, 95%CI, 0.982–0.999). The cut-off value of PLT was 110 × 109/L, and the cut-off value of serum ferritin was 548.4 ng/ml.ConclusionChildren with KD who had a PLT count under 110 × 109/L, and a serum ferritin level over 548.4 ng/ml are more likely to develop KD-MAS.

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