Further Investigation of Synaptic Vesicle Protein 2A (SV2A) Ligands Designed for Positron Emission Tomography and Single-Photon Emission Computed Tomography Imaging: Synthesis and Structure–Activity Relationship of Substituted Pyridinylmethyl-4-(3,5-difluorophenyl)pyrrolidin-2-ones

• Richard Pracitto,
• Kyle C. Wilcox,
• Marcel Lindemann,
• Jie Tong,
• Chao Zheng,
• Songye Li,
• Sjoerd J. Finnema,
• Yiyun Huang,
• Zhengxin Cai

Affiliations

Richard Pracitto

PET Center, Yale University School of Medicine, New Haven, Connecticut, United States

Kyle C. Wilcox

Translational Imaging Neuroscience, AbbVie, North Chicago, Illinois, United States

Marcel Lindemann

PET Center, Yale University School of Medicine, New Haven, Connecticut, United States

Jie Tong

PET Center, Yale University School of Medicine, New Haven, Connecticut, United States

Chao Zheng

PET Center, Yale University School of Medicine, New Haven, Connecticut, United States

Songye Li

PET Center, Yale University School of Medicine, New Haven, Connecticut, United States

Sjoerd J. Finnema

PET Center, Yale University School of Medicine, New Haven, Connecticut, United States

Yiyun Huang

PET Center, Yale University School of Medicine, New Haven, Connecticut, United States

Zhengxin Cai

PET Center, Yale University School of Medicine, New Haven, Connecticut, United States