Green Approach Extraction of Perezone from the Roots of <i>Acourtia platyphilla</i> (A. Grey): A Comparison of Four Activating Modes and Supercritical Carbon Dioxide
René Escobedo-González,
Andrea Vázquez Vázquez Cabañas,
Armando Martínez González,
Pablo Mendoza Sánchez,
Zenaida Saavedra-Leos,
Julián Cruz-Olivares,
Juan Nava Serrano,
Joel Martínez,
René Miranda Ruvalcaba
Affiliations
René Escobedo-González
Department of industrial maintenance and nanotechnology, Technological University of Juarez City, Ciudad Juarez, Chihuahua 32695, Mexico
Andrea Vázquez Vázquez Cabañas
Department of Chemistry, Faculty of Superior Studies Cuautitlan, Campus 1, Autonomous National University of Mexico, Cuautitlan Izcalli, Mexico State 54740, Mexico
Armando Martínez González
Department of Chemistry, Faculty of Superior Studies Cuautitlan, Campus 1, Autonomous National University of Mexico, Cuautitlan Izcalli, Mexico State 54740, Mexico
Pablo Mendoza Sánchez
Department of Chemistry, Faculty of Superior Studies Cuautitlan, Campus 1, Autonomous National University of Mexico, Cuautitlan Izcalli, Mexico State 54740, Mexico
Zenaida Saavedra-Leos
Academic Coordination, Altiplano Region, Autonomous University of San Luis Potosi, Road Cedral km. 5+600, Matehuala, San Luis Potosi 78700, Mexico
Julián Cruz-Olivares
Chemistry Faculty, Autonomous University of Mexico State, Toluca, State of Mexico 501020, Mexico
Juan Nava Serrano
Biological Science National School, National Polytechnic Institute, Mexico City 11340, Mexico
Joel Martínez
Chemistry Science Faculty, Autonomous University of San Luis, Av. Dr. Manuel Nava 6, State of San Luis Potosi 78210, Mexico
René Miranda Ruvalcaba
Department of Chemistry, Faculty of Superior Studies Cuautitlan, Campus 1, Autonomous National University of Mexico, Cuautitlan Izcalli, Mexico State 54740, Mexico
Perezone, a sesquiterpene quinone, is a very important molecule due to its pharmacological activities in addition to the fact that it is considered to be the first secondary metabolite isolated in the new world (America−Mexico, 1852). This study aims to offer a green comparative study about the extraction of the target molecule from the roots of the vegetable specimen Acourtia platyphilla (A. Grey). The study was performed comparing five different modes of extraction: supercritical CO2, electromagnetic infrared and microwave irradiations, mechanical-wave ultrasound versus typical mantle heating procedure. An exhaustive comparative-discussion of the obtained results is provided. It is worth noting that the corresponding quantifications were established using 1H NMR, correlating appropriately the integrals of the vinylic proton H-6 of perezone with the aromatic singlet of p-dinitrobenzene employed as an internal reference. It is also important to highlight that the four presented procedures are novel modes to extract perezone. Finally, a complementary study about the solubility of the target sesquiterpene quinone related to the use of supercritical CO2 is also reported.
