Lipids in Health and Disease (Jun 2011)

Joint effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on risk of hyper-LDL cholesterolemia in middle-aged Japanese men

  • Shirasawa Takako,
  • Ohtsu Tadahiro,
  • Shimada Naoki,
  • Yoshida Masao,
  • Karita Kanae,
  • Matsunaga Naomi,
  • Ishikawa Mamoru,
  • Kokaze Akatsuki,
  • Kawamoto Teruyoshi,
  • Ochiai Hirotaka,
  • Ito Taku,
  • Hoshino Hiromi,
  • Takashima Yutaka

DOI
https://doi.org/10.1186/1476-511X-10-105
Journal volume & issue
Vol. 10, no. 1
p. 105

Abstract

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Abstract Background Combined effects between mitochondrial DNA 5178 (Mt5178) C/A polymorphism and alcohol consumption on the risk of hypertension or hyperuricemia have been reported. The objective of this study was to investigate whether Mt5178 C/A polymorphism modulates the effects of alcohol consumption on the risk of dyslipidemia. Methods A total of 394 male subjects were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the combined effect of Mt5178 polymorphism and alcohol consumption on the risk of dyslipidemia was conducted. Results For men with Mt5178C, alcohol consumption was significantly and negatively associated with the risk of hyper-low-density lipoprotein (LDL) cholesterolemia (serum LDL cholesterol ≥ 140 mg/dl) (P for trend = 0.015). After adjustment for age, body mass index (BMI), habitual smoking, coffee consumption and use of antihypertensive medicine, the odds ratio (OR) for hyper-LDL cholesterolemia was significantly lower in daily drinkers with Mt5178C than non-drinkers with Mt5178C (OR = 0.360, 95% confidence intervals: 0.153-0.847). A significant and negative association between alcohol consumption and serum LDL cholesterol levels was also observed in Mt5178C genotypic men (P for trend Conclusions For Mt5178C genotypic men, alcohol consumption may reduce the risk of hyper-LDL cholesterolemia.