Microwave-Assisted Synthesis of Phenothiazine and Qinoline Derivatives

Abstract

Application of a dynamic microwave power system in the chemical synthesis ofsome phenothiazine and quinoline derivatives is described. Heterocyclic ring formation,aromatic nucleophilic substitution and heterocyclic aldehydes/ketones condensationreactions were performed on solid support, or under solvent free reaction conditions. Themicrowave-assisted Duff formylation of phenothiazine was achieved. Comparison ofmicrowave-assisted synthesis with the conventional synthetic methods demonstratesadvantages related to shorter reaction times and in some cases better reaction yields.

Keywords

• MAOS
• Quinoline
• Pyrido[3,2-g]quinoline
• Phenothiazine
• formylation