Generation of an induced pluripotent stem cell (iPSC) line (THSJTUi001-A) from a Wilson's disease patient harboring a homozygous Arg778Leu mutation in ATP7B gene

Shu-Hong Wang; Xiao-Ping Wang

Stem Cell Research (Dec 2020)

Generation of an induced pluripotent stem cell (iPSC) line (THSJTUi001-A) from a Wilson's disease patient harboring a homozygous Arg778Leu mutation in ATP7B gene

Shu-Hong Wang,
Xiao-Ping Wang

Affiliations

Shu-Hong Wang: Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200050, China
Xiao-Ping Wang: Corresponding author.; Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200050, China

Journal volume & issue: Vol. 49
p. 102050

Abstract

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Induced pluripotent stem cell (iPSC) line, THSJTUi001-A, was generated from a 26-year-old Chinese male patient with Wilson's disease carrying a homozygous Arg778Leu mutation in ATP7B gene, using non-integrated episomal reprogramming vectors. This cell line had normal karyotype, expressed pluripotency markers and could differentiate into the three germ layers in vivo.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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