A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome

Poonam Chitale; Alexander D. Lemenze; Emily C. Fogarty; Avi Shah; Courtney Grady; Aubrey R. Odom-Mabey; W. Evan Johnson; Jason H. Yang; A. Murat Eren; Roland Brosch; Pradeep Kumar; David Alland

doi:10.1038/s41467-022-34853-x

Nature Communications (Nov 2022)

A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome

Poonam Chitale,
Alexander D. Lemenze,
Emily C. Fogarty,
Avi Shah,
Courtney Grady,
Aubrey R. Odom-Mabey,
W. Evan Johnson,
Jason H. Yang,
A. Murat Eren,
Roland Brosch,
Pradeep Kumar,
David Alland

Affiliations

Poonam Chitale: Ray V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University – New Jersey Medical School
Alexander D. Lemenze: Department of Pathology, Immunology and Laboratory Medicine, New Jersey Medical School, Rutgers—The State University of New Jersey
Emily C. Fogarty: Department of Medicine, University of Chicago
Avi Shah: Ray V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University – New Jersey Medical School
Courtney Grady: Ray V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University – New Jersey Medical School
Aubrey R. Odom-Mabey: Division of Computational Biomedicine, Boston University School of Medicine and Bioinformatics Program, Boston University
W. Evan Johnson: Ray V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University – New Jersey Medical School
Jason H. Yang: Ray V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University – New Jersey Medical School
A. Murat Eren: Helmholtz Institute for Functional Marine Biodiversity (HIFMB)
Roland Brosch: Institut Pasteur, Université Paris Cité, Unit for Integrated Mycobacterial Pathogenomics
Pradeep Kumar: Ray V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University – New Jersey Medical School
David Alland: Ray V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University – New Jersey Medical School

DOI: https://doi.org/10.1038/s41467-022-34853-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

H37Rv is the most widely used Mycobacterium tuberculosis strain, and its genome is the reference sequence for this pathogen. Here, Chitale et al. present a bioinformatic pipeline for accurate assembly of bacterial genome sequences, and use it to provide important updates to the M. tuberculosis reference genome.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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