Journal Title: Memórias do Instituto Oswaldo Cruz.
ISSN: 0074-0276 (Print); 1678-8060 (Online)
Publisher: Instituto Oswaldo Cruz, Ministério da Saúde
Society/Institution: Instituto Oswaldo Cruz, Ministério da Saúde
LCC Subject Category: Medicine: Internal medicine: Special situations and conditions: Arctic medicine. Tropical medicine | Science: Microbiology
Country of publisher: Brazil
Language of fulltext: English
Full-text formats available: PDF, HTML, XML
Abstract | Full Text
Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and proposes future therapeutic strategies to modulate the host response in the treatment of periodontitis.