Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis

Memórias do Instituto Oswaldo Cruz.. 2005;100:177-180 DOI 10.1590/S0074-02762005000900030

 

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Journal Title: Memórias do Instituto Oswaldo Cruz.

ISSN: 0074-0276 (Print); 1678-8060 (Online)

Publisher: Instituto Oswaldo Cruz, Ministério da Saúde

Society/Institution: Instituto Oswaldo Cruz, Ministério da Saúde

LCC Subject Category: Medicine: Internal medicine: Special situations and conditions: Arctic medicine. Tropical medicine | Science: Microbiology

Country of publisher: Brazil

Language of fulltext: English

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AUTHORS

M Holzhausen
LC Spolidorio
N Vergnolle

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 16 weeks

 

Abstract | Full Text

Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and proposes future therapeutic strategies to modulate the host response in the treatment of periodontitis.