Novel function of biguanides in inhibition of phospholipase D1 expression via a translational mechanism in cancer cells

• Yuanfa Yao,
• Hanbing Li,
• Xinyi Wang,
• Yuanhai Sun,
• Xuqin Zhao,
• Weiwei Zha,
• Jiaqiang Zhou,
• Derek Toomre,
• Junfen Fu,
• Yingke Xu

Affiliations

Yuanfa Yao

Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Children's Health, Hangzhou, Zhejiang 310051, China; Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Ministry of Education, State Key Laboratory of Modern Optical Instrumentation, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, Zhejiang 310027, China; Institute of Pharmacology, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China

Hanbing Li

Institute of Pharmacology, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China

Xinyi Wang

Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Ministry of Education, State Key Laboratory of Modern Optical Instrumentation, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, Zhejiang 310027, China

Yuanhai Sun

Institute of Pharmacology, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China

Xuqin Zhao

Institute of Pharmacology, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China

Weiwei Zha

Institute of Pharmacology, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China

Jiaqiang Zhou

Department of Endocrinology, The Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China

Derek Toomre

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA

Junfen Fu

Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Children's Health, Hangzhou, Zhejiang 310051, China

Yingke Xu

Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Children's Health, Hangzhou, Zhejiang 310051, China; Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Ministry of Education, State Key Laboratory of Modern Optical Instrumentation, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, Zhejiang 310027, China; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA; Binjiang Institute of Zhejiang University, Hangzhou, Zhejiang 310053, China; Corresponding author. Department of Biomedical Engineering, 38 Zheda Road, Yuquan Campus, Zhejiang University, Hangzhou, Zhejiang 310027, China