Nature Communications (Jul 2019)

Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity

  • Hongdong Wang,
  • Lei Shen,
  • Xitai Sun,
  • Fangcen Liu,
  • Wenhuan Feng,
  • Chunping Jiang,
  • Xuehui Chu,
  • Xiao Ye,
  • Can Jiang,
  • Yan Wang,
  • Pengzi Zhang,
  • Mengwei Zang,
  • Dalong Zhu,
  • Yan Bi

DOI
https://doi.org/10.1038/s41467-019-11270-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Whether adipose ILC1s regulate adipose tissue fibrogenesis is unknown. Here, the authors report a direct role of adipose ILC1s in adipose tissue fibrogenesis and provide insights into the mechanisms of local immune dysfunction in obesity-associated metabolic disorders.