Serjanic Acid Glycosides from <i>Chenopodium hybridum</i> L. with Good Cytotoxicity and Selectivity Profile against Several Panels of Human Cancer Cell Lines
Karolina Grabowska,
Łukasz Pecio,
Agnieszka Galanty,
Paweł Żmudzki,
Wiesław Oleszek,
Irma Podolak
Affiliations
Karolina Grabowska
Department of Pharmacognosy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Cracow, Poland
Łukasz Pecio
Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation–State Research Institute, ul. Czartoryskich 8, 24-100 Puławy, Poland
Agnieszka Galanty
Department of Pharmacognosy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Cracow, Poland
Paweł Żmudzki
Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Cracow, Poland
Wiesław Oleszek
Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation–State Research Institute, ul. Czartoryskich 8, 24-100 Puławy, Poland
Irma Podolak
Department of Pharmacognosy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Cracow, Poland
Two triterpene saponins, including a novel serjanic acid derivative, were isolated from Chenopodium hybridum L. (Amaranthaceae) aerial parts. Their structures were elucidated by a combination of spectroscopic methods (MS, 1D and 2D NMR). Both compounds were evaluated for cytotoxicity and selectivity on skin, prostate, gastrointestinal, thyroid and lung cancer cells. Their effect was dose and time-dependent with varied potency, the highest against prostate PC3 and melanoma WM793, where IC50 was lower than the reference drug doxorubicin. Structure–activity relationship is briefly discussed.
