The Role of Pyroptosis in Oral Infectious Diseases: Current Research Progress

Abstract

In oral infectious diseases, the imbalance of oral microorganisms is considered a primary factor， however, the extent of periodontal tissue destruction is determined by the interaction between microbiota and the host immune response. Pyroptosis, a crucial innate immune response, plays a significant role in the onset and progression of oral infectious diseases. This paper reviews the molecular mechanisms of pyroptosis, the pyroptosis pathways triggered by various oral microorganisms, and the pathophysiological mechanisms of tissue destruction. The aim is to offer novel insights for the prevention and treatment of oral infectious diseases.

Keywords

• pyroptosis
• oral infectious diseases
• periodontitis