Violation of the relationship of metabolic pathways interrelations in vaginal tissue as molecular base of atrophic colpitis formation

Abstract

It was done the analysis of interrelations between different metabolic pathways (which responsible for atrophic colpitis formation) in vagina tissue at women in post reproductive period. The results of our investigation have showed that carbohydrates' metabolism in vagina tissue at atrophic process has changed into pentose phosphate pathway activation, disturbance in end glycolytic products formation. Tri carbonic acids synthesis' velocity was inhibited was depressed in this situation. The composition of fatty acids in vaginal tissue has changed into increasing of polyunsaturated fatty acids quantity. The results of investigation gave us the possibility to deep our imagination about pathogenesis of atrophic process formation in vaginal tissue and shows that the main cause of atrophic process based on changes in cell metabolism due to affection of different enzymatic systems' working.

Keywords

• атрофия
• кольпит
• метаболизм
• atrophy
• colpitis
• metabolism