Diabetes, Metabolic Syndrome and Obesity (Feb 2022)

Association Between Triglyceride-Glucose Index and 2-Year Adverse Cardiovascular and Cerebrovascular Events in Patients with Type 2 Diabetes Mellitus Who Underwent Off-Pump Coronary Artery Bypass Grafting

  • Chen L,
  • Ding XH,
  • Fan KJ,
  • Gao MX,
  • Yu WY,
  • Liu HL,
  • Yu Y

Journal volume & issue
Vol. Volume 15
pp. 439 – 450

Abstract

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Liang Chen, Xiao-Hang Ding, Kang-Jun Fan, Ming-Xin Gao, Wen-Yuan Yu, Hong-Li Liu, Yang Yu Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, People’s Republic of ChinaCorrespondence: Yang Yu, Email [email protected]: Data on the relationship between the triglyceride glucose (TyG) index and prognosis after off-pump coronary artery bypass grafting (OPCABG) are limited. This retrospective observational cohort study evaluated the association of the TyG index with prognosis in patients with diabetes mellitus who underwent OPCABG.Methods: The TyG index was calculated using the following equation: TyG index = ln (fasting triglyceride level [mg/dL] × fasting glucose level [mg/dL]/2). The primary outcomes included the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs), which were defined as all-cause death, nonfatal myocardial infarction, nonfatal stroke and symptomatic graft failure. The association between the TyG index and MACCEs was assessed by Cox proportional hazards regression analysis.Results: A total of 1578 patients with diabetes who underwent OPCABG (mean age, 62.9 ± 8.0 years; men, 72.7%) were enrolled in this study. Over the follow-up of 2 years, 176 patients (11.2%) had at least 1 primary endpoint event. The follow-up incidence of the primary endpoint rose with increasing TyG index tertiles. The multivariate Cox proportional hazards regression analysis adjusted for multiple confounders revealed a hazard ratio for the primary endpoint of 2.133 (95% CI 1.347– 3.377; P for trend = 0.001) when the highest and lowest TyG index tertiles were compared.Conclusion: The TyG index was significantly and positively associated with MACCEs, suggesting that the TyG index may be a valuable predictor of adverse cardiovascular and cerebrovascular outcomes after OPCABG in patients with T2DM.Keywords: triglyceride-glucose index, off-pump coronary artery bypass grafting, major adverse cardiovascular and cerebrovascular events, type 2 diabetes mellitus

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