Encyclopedia
(Jul 2021)
Dnase1 Family in Autoimmunity
Minal Engavale,
Jon McCord,
Britney Mapp,
Nadine Nzimulinda,
Elisabeth Bengtson,
R. Bryan Sutton,
Peter A. Keyel
Affiliations
Minal Engavale
Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA
Jon McCord
Department of Cell Physiology and Molecular Biophysics, Texas Tech University Health Science Center, Lubbock, TX 79430, USA
Britney Mapp
Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA
Nadine Nzimulinda
Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA
Elisabeth Bengtson
Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA
R. Bryan Sutton
Department of Cell Physiology and Molecular Biophysics, Texas Tech University Health Science Center, Lubbock, TX 79430, USA
Peter A. Keyel
Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA
DOI
https://doi.org/10.3390/encyclopedia1030044
Journal volume & issue
Vol. 1,
no. 3
Abstract
Read online
The deoxyribonuclease 1 (Dnase1) family is a key family of endonucleases that degrades DNA. Loss of Dnase1 family function causes several diseases where the host’s immune system targets the host, such as systemic lupus erythematosus, hypocomplementemic urticarial vasculitis syndrome.
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