Frontiers in Aging Neuroscience (Nov 2023)

Effects of the multidomain intervention with nutritional supplements on cognition and gut microbiome in early symptomatic Alzheimer’s disease: a randomized controlled trial

  • Eun Hye Lee,
  • Eun Hye Lee,
  • Geon Ha Kim,
  • Geon Ha Kim,
  • Hee Kyung Park,
  • Hae Jin Kang,
  • Yoo Kyoung Park,
  • Hye Ah Lee,
  • Chang Hyung Hong,
  • So Young Moon,
  • Woorim Kang,
  • Hyun-Seok Oh,
  • Hai-Jeon Yoon,
  • Seong Hye Choi,
  • Jee Hyang Jeong,
  • Jee Hyang Jeong

DOI
https://doi.org/10.3389/fnagi.2023.1266955
Journal volume & issue
Vol. 15

Abstract

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BackgroundThe SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN) is a part of the World-Wide Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (WW-FINGERS) network. This study aimed to demonstrate the effects of the SUPERBRAIN-based multidomain intervention with nutritional supplements in amyloid positive emission tomography (PET) proven early symptomatic Alzheimer’s disease patients.MethodsForty-six participants who were diagnosed with mild cognitive impairment or mild dementia and were positive in the amyloid PET study randomized into three groups: group A, the multidomain intervention with nutritional supplements; group B, nutritional supplements only; and a control group. The primary outcome was a change in the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) total scale index score after an 8-week intervention. Secondary outcomes, including gut microbiome data, were also analyzed.ResultsThe RBANS total scale index score improved significantly in group A compared with group B (p < 0.032) and compared with the control group (p < 0.001). After intervention, beta diversity of the gut microbiome between group A and the control group increased, and patients in group A were more enriched with Bifidobacterium.ConclusionSUPERBRAIN-based multidomain intervention with nutritional supplements improves cognition and gut microbiota in patients with early symptomatic Alzheimer’s disease who were amyloid-positive by PET.

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