Animal Models and Experimental Medicine (Mar 2020)
Age‐related rhesus macaque models of COVID‐19
- Pin Yu,
- Feifei Qi,
- Yanfeng Xu,
- Fengdi Li,
- Peipei Liu,
- Jiayi Liu,
- Linlin Bao,
- Wei Deng,
- Hong Gao,
- Zhiguang Xiang,
- Chong Xiao,
- Qi Lv,
- Shuran Gong,
- Jiangning Liu,
- Zhiqi Song,
- Yajin Qu,
- Jing Xue,
- Qiang Wei,
- Mingya Liu,
- Guanpeng Wang,
- Shunyi Wang,
- Haisheng Yu,
- Xing Liu,
- Baoying Huang,
- Wenling Wang,
- Li Zhao,
- Huijuan Wang,
- Fei Ye,
- Weimin Zhou,
- Wei Zhen,
- Jun Han,
- Guizhen Wu,
- Qi Jin,
- Jianwei Wang,
- Wenjie Tan,
- Chuan Qin
Affiliations
- Pin Yu
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Feifei Qi
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Yanfeng Xu
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Fengdi Li
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Peipei Liu
- MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC Beijing China
- Jiayi Liu
- Department of Radiology Bejing Anzhen Hospital Capital Medical University Beijing China
- Linlin Bao
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Wei Deng
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Hong Gao
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Zhiguang Xiang
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Chong Xiao
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Qi Lv
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Shuran Gong
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Jiangning Liu
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Zhiqi Song
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Yajin Qu
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Jing Xue
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Qiang Wei
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Mingya Liu
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Guanpeng Wang
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Shunyi Wang
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Haisheng Yu
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Xing Liu
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- Baoying Huang
- MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC Beijing China
- Wenling Wang
- MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC Beijing China
- Li Zhao
- MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC Beijing China
- Huijuan Wang
- MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC Beijing China
- Fei Ye
- MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC Beijing China
- Weimin Zhou
- MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC Beijing China
- Wei Zhen
- MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC Beijing China
- Jun Han
- MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC Beijing China
- Guizhen Wu
- MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC Beijing China
- Qi Jin
- Institute of Pathogen Biology Chinese Academy of Medical Sciences Beijing China
- Jianwei Wang
- Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
- Wenjie Tan
- MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Prevention China CDC Beijing China
- Chuan Qin
- Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of Health Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine Center Peking Union Medical College Beijing China
- DOI
- https://doi.org/10.1002/ame2.12108
- Journal volume & issue
-
Vol. 3,
no. 1
pp. 93 – 97
Abstract
Abstract Background Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a need to explore the possible age‐related phenomena with non‐human primate models. Methods Three 3‐5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS‐CoV‐2, and then analyzed by clinical signs, viral replication, chest X‐ray, histopathological changes and immune response. Results Viral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS‐CoV‐2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages. Conclusion SARS‐CoV‐2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS‐CoV‐2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS‐CoV‐2 infection.
Keywords
