Electrodeposited magnetic nanoporous membrane for high-yield and high-throughput immunocapture of extracellular vesicles and lipoproteins

Chenguang Zhang; Xiaoye Huo; Yini Zhu; James N. Higginbotham; Zheng Cao; Xin Lu; Jeffrey L. Franklin; Kasey C. Vickers; Robert J. Coffey; Satyajyoti Senapati; Ceming Wang; Hsueh-Chia Chang

doi:10.1038/s42003-022-04321-9

Communications Biology (Dec 2022)

Electrodeposited magnetic nanoporous membrane for high-yield and high-throughput immunocapture of extracellular vesicles and lipoproteins

Chenguang Zhang,
Xiaoye Huo,
Yini Zhu,
James N. Higginbotham,
Zheng Cao,
Xin Lu,
Jeffrey L. Franklin,
Kasey C. Vickers,
Robert J. Coffey,
Satyajyoti Senapati,
Ceming Wang,
Hsueh-Chia Chang

Affiliations

Chenguang Zhang: Department of Chemical and Biomolecular Engineering, University of Notre Dame
Xiaoye Huo: Department of Chemical and Biomolecular Engineering, University of Notre Dame
Yini Zhu: Department of Biology, University of Notre Dame
James N. Higginbotham: Department of Medicine, Vanderbilt University Medical Center
Zheng Cao: Department of Medicine, Vanderbilt University Medical Center
Xin Lu: Department of Biology, University of Notre Dame
Jeffrey L. Franklin: Department of Medicine, Vanderbilt University Medical Center
Kasey C. Vickers: Department of Medicine, Vanderbilt University Medical Center
Robert J. Coffey: Department of Medicine, Vanderbilt University Medical Center
Satyajyoti Senapati: Department of Chemical and Biomolecular Engineering, University of Notre Dame
Ceming Wang: Aopia Biosciences, 31351 Medallion Dr
Hsueh-Chia Chang: Department of Chemical and Biomolecular Engineering, University of Notre Dame

DOI: https://doi.org/10.1038/s42003-022-04321-9
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

Read online

A magnetic nanoporous membrane is engineered for immunocapture of extracellular vesicles and lipoproteins in heterogeneous physiological fluids, such as plasma and saliva, and quantification of cargo and biomarkers in these nanocarriers.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal