Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy

Fabio A. Iannotti; Ester Pagano; Ombretta Guardiola; Simone Adinolfi; Valentina Saccone; Silvia Consalvi; Fabiana Piscitelli; Elisabetta Gazzerro; Giuseppe Busetto; Diego Carrella; Raffaele Capasso; Pier Lorenzo Puri; Gabriella Minchiotti; Vincenzo Di Marzo

doi:10.1038/s41467-018-06267-1

Nature Communications (Sep 2018)

Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy

Fabio A. Iannotti,
Ester Pagano,
Ombretta Guardiola,
Simone Adinolfi,
Valentina Saccone,
Silvia Consalvi,
Fabiana Piscitelli,
Elisabetta Gazzerro,
Giuseppe Busetto,
Diego Carrella,
Raffaele Capasso,
Pier Lorenzo Puri,
Gabriella Minchiotti,
Vincenzo Di Marzo

Affiliations

Fabio A. Iannotti: Endocannabinoid Research Group, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR)
Ester Pagano: Department of Pharmacy, University of Naples Federico II
Ombretta Guardiola: Institute of Genetics and Biophysics, National Research Council (CNR)
Simone Adinolfi: Endocannabinoid Research Group, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR)
Valentina Saccone: IRCCS Fondazione Santa Lucia Rome
Silvia Consalvi: IRCCS Fondazione Santa Lucia Rome
Fabiana Piscitelli: Endocannabinoid Research Group, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR)
Elisabetta Gazzerro: Gaslini Children’s Hospital
Giuseppe Busetto: Department of Neuroscience Biomedicine and Movement, Section of Physiology and Psychology, University of Verona
Diego Carrella: Telethon Institute of Genetics and Medicine (TIGEM)
Raffaele Capasso: Department of Agricultural Sciences, University of Naples Federico II
Pier Lorenzo Puri: IRCCS Fondazione Santa Lucia Rome
Gabriella Minchiotti: Institute of Genetics and Biophysics, National Research Council (CNR)
Vincenzo Di Marzo: Endocannabinoid Research Group, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR)

DOI: https://doi.org/10.1038/s41467-018-06267-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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The regenerative capacity of muscle stem cells is impaired in Duchenne muscular dystrophy (DMD). Here, the authors show that the endocannabinoid receptor CB1 is activated by PAX7 in muscle stem cells, and that pharmacological inhibition of CB1 promotes stem cell activation and ameliorates symptoms in DMD mouse models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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