Associated Factors of Osteoporosis in Elderly Patients with Stable Chronic Conditions

Abstract

Background China is seeing increasingly osteoporosis prevalence as ageing marches on. However, the specific etiology and pathogenesis of osteoporosis are still unclear, and there are still limitations in its prevention and treatment. Objective To investigate osteoporosis prevalence and associated factors in older Chinese patients with stable chronic conditions. Methods Three hundred and two elderly inpatients with stable chronic conditions who underwent a reexamination in Department of Geriatrics, Yunnan First People's Hospital from November 2020 to September 2021 were recruited. Dual-energy X-ray absorptiometry (DXA) was used to measure lumbar spine and hip bone mineral density (BMD) . T value ≤-2.5 was defined as osteoporosis. Demographic data were collected. Comprehensive geriatric assessment was conducted via a self-developed online platform named Comprehensive Geriatric Assessment. Fasting venous blood samples were collected and measured for serum biomarkers. Results Among the patients, 126 (41.7%) were found with osteoporosis, and other 176 (58.3%) without. Binary Logistic regression analysis indicated that insomnia〔OR=2.180, 95%CI (1.080, 4.443) 〕, multiple chronic conditions〔OR=1.223, 95%CI (1.101, 1.358) 〕, elevated homocysteine〔OR=1.043, 95%CI (1.000, 1.088) 〕 were associated with increased risk of osteoporosis (P<0.05) , while elevated serum uric acid level〔OR=0.996, 95%CI (0.993, 0.999) 〕 was associated with decreased risk of osteoporosis (P<0.05) . Conclusion The prevalence of osteoporosis in these older patients with stable chronic conditions was 41.7%. The probability of osteoporosis may be decreased with elevated serum uric acid level, and increased with elevated homocysteine, insomnia and multiple chronic conditions.

Keywords

• osteoporosis|aged|uric acid|homocysteine|insomnia|chronic disease|multiple chronic conditions|senile syndrome