Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms

Hitomi Matsuzaki; Yu Miyajima; Akiyoshi Fukamizu; Keiji Tanimoto

doi:10.1038/s42003-021-02939-9

Communications Biology (Dec 2021)

Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms

Hitomi Matsuzaki,
Yu Miyajima,
Akiyoshi Fukamizu,
Keiji Tanimoto

Affiliations

Hitomi Matsuzaki: Faculty of Life and Environmental Sciences, University of Tsukuba
Yu Miyajima: Graduate school of Life and Environmental Sciences, University of Tsukuba
Akiyoshi Fukamizu: Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba
Keiji Tanimoto: Faculty of Life and Environmental Sciences, University of Tsukuba

DOI: https://doi.org/10.1038/s42003-021-02939-9
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

Read online

Hitomi Matsuzaki et al. test the effect of reversing the H19/Igf2 imprinting control region (ICR) in mice. Their results suggest that the polarity of the ICR is involved in controlling imprinted H19 expression in both parental alleles, dependent or independent of DNA methylation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal