Changes within the central stalk of E. coli F1Fo ATP synthase observed after addition of ATP

Meghna Sobti; Yi C. Zeng; James L. Walshe; Simon H. J. Brown; Robert Ishmukhametov; Alastair G. Stewart

doi:10.1038/s42003-023-04414-z

Communications Biology (Jan 2023)

Changes within the central stalk of E. coli F1Fo ATP synthase observed after addition of ATP

Meghna Sobti,
Yi C. Zeng,
James L. Walshe,
Simon H. J. Brown,
Robert Ishmukhametov,
Alastair G. Stewart

Affiliations

Meghna Sobti: Molecular, Structural and Computational Biology Division, The Victor Chang Cardiac Research Institute
Yi C. Zeng: Molecular, Structural and Computational Biology Division, The Victor Chang Cardiac Research Institute
James L. Walshe: Molecular, Structural and Computational Biology Division, The Victor Chang Cardiac Research Institute
Simon H. J. Brown: Molecular Horizons, University of Wollongong, and Illawarra Health and Medical Research Institute
Robert Ishmukhametov: Department of Physics, Clarendon Laboratory, University of Oxford
Alastair G. Stewart: Molecular, Structural and Computational Biology Division, The Victor Chang Cardiac Research Institute

DOI: https://doi.org/10.1038/s42003-023-04414-z
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 9

Abstract

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Cryo-EM structures of E. coli F1Fo ATP synthase highlight the role of the inhibitory ε subunit in regulating the torsional movement of the central stalk within the Fo motor and central stalk flexibility in coupling the F1 and Fo motors.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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