Molar pregnancy after in vitro fertilization with euploid single embryo transfer

Abstract

Objective: To describe a case of molar pregnancy after in vitro fertilization (IVF) resulting from the transfer of a euploid embryo derived from a monopronuclear zygote. Design: Case report and review of the literature. Setting: Private practice IVF center. Patient(s): A 42-year-old woman, gravida 3 para 0, with advanced maternal age and infertility who underwent IVF. Intervention(s): Preimplantation genetic testing for aneuploidy using next-generation sequencing, single frozen euploid blastocyst transfer, and medical management of suspected missed abortion. Main Outcome Measure(s): Genetic examination of products of conception and correlation with embryonic preimplantation genetic testing for aneuploidy results. Result(s): Transfer of the euploid embryo derived from an abnormally fertilized oocyte (monopronuclear zygote) resulted in a clinical pregnancy suspected to be a missed abortion. Products of conception collected after medical management of the suspected missed abortion were analyzed using next-generation sequencing with the report “46,XX complete molar pregnancy”. Conclusion(s): To our knowledge, this is the first account of a complete molar pregnancy resulting from the transfer of a reported euploid embryo, highlighting the importance of understanding the limitations of genetic testing platforms in the setting of abnormally fertilized oocyte-derived embryos.

Keywords

• Assisted reproductive technology
• preimplantation genetic testing
• molar pregnancy