Nature Communications (Nov 2021)

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types

  • Benjamin J. Schmiedel,
  • Job Rocha,
  • Cristian Gonzalez-Colin,
  • Sourya Bhattacharyya,
  • Ariel Madrigal,
  • Christian H. Ottensmeier,
  • Ferhat Ay,
  • Vivek Chandra,
  • Pandurangan Vijayanand

DOI
https://doi.org/10.1038/s41467-021-26888-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Immune cells are important in the pathogenesis of COVID-19. Here the authors assessed the effects of COVID-19-risk variants on gene expression in a range of immune cell types, highlighting their potential to impact the function of diverse immune cell types and influence severe disease.