Structure-Based Design of CBP/EP300 Degraders: When Cooperativity Overcomes Affinity

• Iván Cheng-Sánchez,
• Katherine Gosselé,
• Leonardo Palaferri,
• Eleen Laul,
• Gionata Riccabella,
• Rajiv K. Bedi,
• Yaozong Li,
• Anna Müller,
• Ivan Corbeski,
• Amedeo Caflisch,
• Cristina Nevado

Affiliations

Iván Cheng-Sánchez

Department of Chemistry, University of Zurich, Zurich, Switzerland

Katherine Gosselé

Department of Chemistry, University of Zurich, Zurich, Switzerland

Leonardo Palaferri

Department of Chemistry, University of Zurich, Zurich, Switzerland

Eleen Laul

Department of Chemistry, University of Zurich, Zurich, Switzerland

Gionata Riccabella

Department of Chemistry, University of Zurich, Zurich, Switzerland

Rajiv K. Bedi

Department of Biochemistry, University of Zurich, Zurich, Switzerland

Yaozong Li

Department of Biochemistry, University of Zurich, Zurich, Switzerland

Anna Müller

Department of Biochemistry, University of Zurich, Zurich, Switzerland

Ivan Corbeski

Department of Biochemistry, University of Zurich, Zurich, Switzerland

Amedeo Caflisch

Department of Biochemistry, University of Zurich, Zurich, Switzerland

Cristina Nevado

Department of Chemistry, University of Zurich, Zurich, Switzerland