Diagnostic performance of machine learning in systemic infection following percutaneous nephrolithotomy and identification of associated risk factors
Pengju Li,
Yiming Tang,
Qinsong Zeng,
Chengqiang Mo,
Nur Ali,
Baohua Bai,
Song Ji,
Yubing Zhang,
Junhang Luo,
Hui Liang,
Rongpei Wu
Affiliations
Pengju Li
Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China
Yiming Tang
Department of Urology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China
Qinsong Zeng
Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China
Chengqiang Mo
Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China
Nur Ali
Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China
Baohua Bai
Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China
Song Ji
Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China
Yubing Zhang
Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China
Junhang Luo
Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China; Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China; Corresponding author. Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, No. 58, Zhongshan road II, Guangzhou, 510080, PR China.
Hui Liang
Department of Urology, Affiliated Longhua People's Hospital, Southern Medical University, Shenzhen, PR China; Corresponding author. Department of Urology, Affiliated Longhua People's Hospital, Southern Medical University, No.38 Jianshe East Road, Shenzhen City, Guangdong Province, 518109, PR China.
Rongpei Wu
Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China; Corresponding author. Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, No. 58, Zhongshan road II, Guangzhou, 510080, PR China.
Objective: This study aims to investigate the predictive performance of machine learning in predicting the occurrence of systemic inflammatory response syndrome (SIRS) and urosepsis after percutaneous nephrolithotomy (PCNL). Methods: A retrospective analysis was conducted on patients who underwent PCNL treatment between January 2016 and July 2022. Machine learning techniques were employed to establish and select the best predictive model for postoperative systemic infection. The feasibility of using relevant risk factors as predictive markers was explored through interpretability with Machine Learning. Results: A total of 1067 PCNL patients were included in this study, with 111 (10.4 %) patients developing SIRS and 49 (4.5 %) patients developing urosepsis. In the validation set, the risk model based on the GBM protocol demonstrated a predictive power of 0.871 for SIRS and 0.854 for urosepsis. Preoperative and postoperative platelet changes were identified as the most significant predictors. Both thrombocytopenia and thrombocytosis were found to be risk factors for SIRS or urosepsis after PCNL. Furthermore, it was observed that when the change in platelet count before and after PCNL surgery exceeded 30*109/L (whether an increase or decrease), the risk of developing SIRS or urosepsis significantly increased. Conclusion: Machine learning can be effectively utilized for predicting the occurrence of SIRS or urosepsis after PCNL. The changes in platelet count before and after PCNL surgery serve as important predictors.
