The Comparison of the effect of High Intensity Interval and Progressive Resistance Training on Activated Transcription Factor 3 myocardial gene expression in male Diabetic Rats

Abstract

Purpose: According to the controversy about the role of ATF3 as a non-inflammatory index of myocardia in metabolic abnormalities as diabetes, the purpose of this study was to compare the effect of high intensity interval versus progressive resistance training on ATF3 myocardial gene expression of male diabetic rats.Methods: Sixty male six weeks rats with a weighing average of 150 g were randomly divided into five groups: diabetic (D), diabetes- high intensity interval training (DIT), high intensity interval training (HIIT), resistance (RT), and diabetes- resistance training (DRT). High intensity interval training included 10 repetitions of one minute running on a treadmill with two minutes of rest. Progressive resistance training included four climb of a resistance ladder with weights. The training program was performed three days a week for six weeks. Data analysis was performed using Fisher's and M-ANOVA tests at a significant level of P ≤ 0.01.Results: Significant increase in expression of ATF3 in diabetes- high intensity interval training group was observed between diabetes and diabetes- high intensity interval training (P <0.001). Between two groups of diabetes and diabetes- resistance training (P = 0.001), there was a significant increase in expression in diabetes- resistance training. In comparison between DIT and DRT groups, progressive respond were observed in DIT versus DRT (P = 0.03).Conclusion: high intensity interval training has been shown to be more effective in comparison with the progressive resistance training, because it activates more different molecular cell mechanisms, perhaps, significantly reduces the negative effects of diabetes mellitus on cardiovascular disease.

Keywords

• active transcription factor 3
• heart tissue
• high intensity interval training
• diabetes