Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives
Han Luo,
Yong-Feng Lv,
Hong Zhang,
Jiang-Miao Hu,
Hong-Mei Li,
Shou-Jin Liu
Affiliations
Han Luo
College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230011, China
Yong-Feng Lv
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
Hong Zhang
College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230011, China
Jiang-Miao Hu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
Hong-Mei Li
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
Shou-Jin Liu
College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230011, China
A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds 14 and 17 exhibited significant cytotoxicity of all five cancer cell lines.
