Nature Communications (Jun 2017)
Genetic loci associated with heart rate variability and their effects on cardiac disease risk
- Ilja M. Nolte,
- M. Loretto Munoz,
- Vinicius Tragante,
- Azmeraw T. Amare,
- Rick Jansen,
- Ahmad Vaez,
- Benedikt von der Heyde,
- Christy L. Avery,
- Joshua C. Bis,
- Bram Dierckx,
- Jenny van Dongen,
- Stephanie M. Gogarten,
- Philippe Goyette,
- Jussi Hernesniemi,
- Ville Huikari,
- Shih-Jen Hwang,
- Deepali Jaju,
- Kathleen F. Kerr,
- Alexander Kluttig,
- Bouwe P. Krijthe,
- Jitender Kumar,
- Sander W. van der Laan,
- Leo-Pekka Lyytikäinen,
- Adam X. Maihofer,
- Arpi Minassian,
- Peter J. van der Most,
- Martina Müller-Nurasyid,
- Michel Nivard,
- Erika Salvi,
- James D. Stewart,
- Julian F. Thayer,
- Niek Verweij,
- Andrew Wong,
- Delilah Zabaneh,
- Mohammad H. Zafarmand,
- Abdel Abdellaoui,
- Sulayma Albarwani,
- Christine Albert,
- Alvaro Alonso,
- Foram Ashar,
- Juha Auvinen,
- Tomas Axelsson,
- Dewleen G. Baker,
- Paul I. W. de Bakker,
- Matteo Barcella,
- Riad Bayoumi,
- Rob J. Bieringa,
- Dorret Boomsma,
- Gabrielle Boucher,
- Annie R. Britton,
- Ingrid Christophersen,
- Andrea Dietrich,
- George B. Ehret,
- Patrick T. Ellinor,
- Markku Eskola,
- Janine F. Felix,
- John S. Floras,
- Oscar H. Franco,
- Peter Friberg,
- Maaike G. J. Gademan,
- Mark A. Geyer,
- Vilmantas Giedraitis,
- Catharina A. Hartman,
- Daiane Hemerich,
- Albert Hofman,
- Jouke-Jan Hottenga,
- Heikki Huikuri,
- Nina Hutri-Kähönen,
- Xavier Jouven,
- Juhani Junttila,
- Markus Juonala,
- Antti M. Kiviniemi,
- Jan A. Kors,
- Meena Kumari,
- Tatiana Kuznetsova,
- Cathy C. Laurie,
- Joop D. Lefrandt,
- Yong Li,
- Yun Li,
- Duanping Liao,
- Marian C. Limacher,
- Henry J. Lin,
- Cecilia M. Lindgren,
- Steven A. Lubitz,
- Anubha Mahajan,
- Barbara McKnight,
- Henriette Meyer zu Schwabedissen,
- Yuri Milaneschi,
- Nina Mononen,
- Andrew P. Morris,
- Mike A. Nalls,
- Gerjan Navis,
- Melanie Neijts,
- Kjell Nikus,
- Kari E. North,
- Daniel T. O'Connor,
- Johan Ormel,
- Siegfried Perz,
- Annette Peters,
- Bruce M. Psaty,
- Olli T. Raitakari,
- Victoria B. Risbrough,
- Moritz F. Sinner,
- David Siscovick,
- Johannes H. Smit,
- Nicholas L. Smith,
- Elsayed Z. Soliman,
- Nona Sotoodehnia,
- Jan A. Staessen,
- Phyllis K. Stein,
- Adrienne M. Stilp,
- Katarzyna Stolarz-Skrzypek,
- Konstantin Strauch,
- Johan Sundström,
- Cees A. Swenne,
- Ann-Christine Syvänen,
- Jean-Claude Tardif,
- Kent D. Taylor,
- Alexander Teumer,
- Timothy A. Thornton,
- Lesley E. Tinker,
- André G. Uitterlinden,
- Jessica van Setten,
- Andreas Voss,
- Melanie Waldenberger,
- Kirk C. Wilhelmsen,
- Gonneke Willemsen,
- Quenna Wong,
- Zhu-Ming Zhang,
- Alan B. Zonderman,
- Daniele Cusi,
- Michele K. Evans,
- Halina K. Greiser,
- Pim van der Harst,
- Mohammad Hassan,
- Erik Ingelsson,
- Marjo-Riitta Järvelin,
- Stefan Kääb,
- Mika Kähönen,
- Mika Kivimaki,
- Charles Kooperberg,
- Diana Kuh,
- Terho Lehtimäki,
- Lars Lind,
- Caroline M. Nievergelt,
- Chris J. O'Donnell,
- Albertine J. Oldehinkel,
- Brenda Penninx,
- Alexander P. Reiner,
- Harriëtte Riese,
- Arie M. van Roon,
- John D. Rioux,
- Jerome I. Rotter,
- Tamar Sofer,
- Bruno H. Stricker,
- Henning Tiemeier,
- Tanja G. M. Vrijkotte,
- Folkert W. Asselbergs,
- Bianca J. J. M. Brundel,
- Susan R. Heckbert,
- Eric A. Whitsel,
- Marcel den Hoed,
- Harold Snieder,
- Eco J. C. de Geus
Affiliations
- Ilja M. Nolte
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- M. Loretto Munoz
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Vinicius Tragante
- Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht
- Azmeraw T. Amare
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Rick Jansen
- Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest
- Ahmad Vaez
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Benedikt von der Heyde
- Department of Medical Sciences, Molecular Epidemiology, Uppsala University
- Christy L. Avery
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Joshua C. Bis
- Department of Medicine, Cardiovascular Health Research Unit, University of Washington
- Bram Dierckx
- Department of Child and Adolescent Psychiatry/Psychology, Department of Child and Adolescent Psychiatry
- Jenny van Dongen
- Department of Biological Psychology, Behavioral and Movement Sciences, VU University
- Stephanie M. Gogarten
- Department of Biostatistics, School of Public Health, University of Washington
- Philippe Goyette
- Montreal Heart Institute
- Jussi Hernesniemi
- Department of Clinical Chemistry, Fimlab Laboratories
- Ville Huikari
- Center for Life Course Health Research, University of Oulu
- Shih-Jen Hwang
- Framingham Heart Study
- Deepali Jaju
- Department of Clinical Physiology, Sultan Qaboos University Hospital
- Kathleen F. Kerr
- Department of Biostatistics, School of Public Health, University of Washington
- Alexander Kluttig
- Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg
- Bouwe P. Krijthe
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Jitender Kumar
- Department of Medical Sciences, Molecular Epidemiology, Uppsala University
- Sander W. van der Laan
- Department of Heart and Lung, Laboratory of Experimental Cardiology, University Medical Center Utrecht
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories
- Adam X. Maihofer
- Department of Psychiatry, University of California, San Diego
- Arpi Minassian
- Department of Psychiatry, University of California, San Diego
- Peter J. van der Most
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Martina Müller-Nurasyid
- Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health
- Michel Nivard
- Department of Biological Psychology, Behavioral and Movement Sciences, VU University
- Erika Salvi
- Department of Health Sciences, University of Milano
- James D. Stewart
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Julian F. Thayer
- Department of Psychology, The Ohio State University
- Niek Verweij
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Andrew Wong
- MRC Unit for Lifelong Health and Ageing, University College London
- Delilah Zabaneh
- Institute of Psychiatry, Psychology & Neuroscience, King's College London
- Mohammad H. Zafarmand
- Department of Public Health, Academic Medical Center (AMC), University of Amsterdam
- Abdel Abdellaoui
- Department of Biological Psychology, Behavioral and Movement Sciences, VU University
- Sulayma Albarwani
- Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University
- Christine Albert
- Brigham and Women's Hospital, Harvard Medical School
- Alvaro Alonso
- Department of Epidemiology, Rollins School of Public Health, Emory University
- Foram Ashar
- McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
- Juha Auvinen
- Center for Life Course Health Research, University of Oulu
- Tomas Axelsson
- Department of Medical Sciences, Molecular Medicine, Uppsala University
- Dewleen G. Baker
- Department of Psychiatry, University of California, San Diego
- Paul I. W. de Bakker
- Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht
- Matteo Barcella
- Department of Health Sciences, University of Milano
- Riad Bayoumi
- College of Medicine, Mohammed Bin Rashid University
- Rob J. Bieringa
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Dorret Boomsma
- Department of Biological Psychology, Behavioral and Movement Sciences, VU University
- Gabrielle Boucher
- Montreal Heart Institute
- Annie R. Britton
- Department of Epidemiology and Public Health, University College London
- Ingrid Christophersen
- Cardiovascular Research Center, Massachusetts General Hospital
- Andrea Dietrich
- Department of Child- and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen
- George B. Ehret
- Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
- Patrick T. Ellinor
- Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT
- Markku Eskola
- Department of Cardiology, Heart Hospital, Tampere University Hospital
- Janine F. Felix
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- John S. Floras
- University Health Network and Mount Sinai Hospital Division of Cardiology, Department of Medicine, University of Toronto
- Oscar H. Franco
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Peter Friberg
- Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg
- Maaike G. J. Gademan
- Department of Public Health, Academic Medical Center (AMC), University of Amsterdam
- Mark A. Geyer
- Department of Psychiatry, University of California, San Diego
- Vilmantas Giedraitis
- Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University
- Catharina A. Hartman
- Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen
- Daiane Hemerich
- Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht
- Albert Hofman
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Jouke-Jan Hottenga
- Department of Biological Psychology, Behavioral and Movement Sciences, VU University
- Heikki Huikuri
- Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu
- Nina Hutri-Kähönen
- Department of Pediatrics, Tampere University Hospital
- Xavier Jouven
- INSERM U970, Paris Descartes University
- Juhani Junttila
- Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu
- Markus Juonala
- Department of Medicine, University of Turku
- Antti M. Kiviniemi
- Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu
- Jan A. Kors
- Department of Medical Informatics, Erasmus Medical Center
- Meena Kumari
- Department of Epidemiology and Public Health, University College London
- Tatiana Kuznetsova
- KU Leuven Department of Cardiovascular Sciences, Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, University of Leuven
- Cathy C. Laurie
- Department of Biostatistics, School of Public Health, University of Washington
- Joop D. Lefrandt
- Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen
- Yong Li
- Division of Genetic Epidemiology, Institute for Medical Biometry and Statistics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg
- Yun Li
- Department of Genetics, University of North Carolina
- Duanping Liao
- Division of Epidemiology, Department of Public Health Sciences, Penn State University College of Medicine
- Marian C. Limacher
- Division of Cardiovascular Medicine, University of Florida College of Medicine
- Henry J. Lin
- Department of Pediatrics, Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Cecilia M. Lindgren
- Li Ka Shing Centre for Health Information and Discovery, The Big Data Institute, University of Oxford
- Steven A. Lubitz
- Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT
- Anubha Mahajan
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Barbara McKnight
- Department of Medicine, Cardiovascular Health Research Unit, University of Washington
- Henriette Meyer zu Schwabedissen
- Department Pharmaceutical Sciences, Biopharmacy, University of Basel
- Yuri Milaneschi
- Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest
- Nina Mononen
- Department of Clinical Chemistry, Fimlab Laboratories
- Andrew P. Morris
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Mike A. Nalls
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Gerjan Navis
- Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen
- Melanie Neijts
- Department of Biological Psychology, Behavioral and Movement Sciences, VU University
- Kjell Nikus
- Department of Cardiology, Heart Hospital, Tampere University Hospital
- Kari E. North
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Daniel T. O'Connor
- Department of Medicine, University of California, San Diego
- Johan Ormel
- Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen
- Siegfried Perz
- Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health
- Annette Peters
- DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance
- Bruce M. Psaty
- Department of Medicine, Cardiovascular Health Research Unit, University of Washington
- Olli T. Raitakari
- Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital
- Victoria B. Risbrough
- Department of Psychiatry, University of California, San Diego
- Moritz F. Sinner
- Department of Medicine, University Hospital Munich, Ludwig-Maximilians-University
- David Siscovick
- The New York Academy of Medicine
- Johannes H. Smit
- Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest
- Nicholas L. Smith
- Group Health Research Institute, Group Health Cooperative
- Elsayed Z. Soliman
- Division of Public Health Sciences, Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine
- Nona Sotoodehnia
- Division of Cardiology, Departments of Medicine and Epidemiology, Cardiovascular Health Research Unit, University of Washington
- Jan A. Staessen
- KU Leuven Department of Cardiovascular Sciences, Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, University of Leuven
- Phyllis K. Stein
- Heart Rate Variability Lab, Washington University School of Medicine
- Adrienne M. Stilp
- Department of Biostatistics, School of Public Health, University of Washington
- Katarzyna Stolarz-Skrzypek
- First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College
- Konstantin Strauch
- Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health
- Johan Sundström
- Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University
- Cees A. Swenne
- Department of Cardiology, Leiden University Medical Center
- Ann-Christine Syvänen
- Department of Medical Sciences, Molecular Medicine, Uppsala University
- Jean-Claude Tardif
- Montreal Heart Institute
- Kent D. Taylor
- Departments of Pediatrics and Medicine, Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Alexander Teumer
- Institute for Community Medicine, University Medicine Greifswald
- Timothy A. Thornton
- Department of Biostatistics, School of Public Health, University of Washington
- Lesley E. Tinker
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- André G. Uitterlinden
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Jessica van Setten
- Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht
- Andreas Voss
- Institute of Innovative Health Technologies—IGHT Jena Ernst-Abbe-Hochschule Jena
- Melanie Waldenberger
- Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health
- Kirk C. Wilhelmsen
- Departments of Genetics and Neurology University of North Carolina
- Gonneke Willemsen
- Department of Biological Psychology, Behavioral and Movement Sciences, VU University
- Quenna Wong
- Department of Biostatistics, School of Public Health, University of Washington
- Zhu-Ming Zhang
- Division of Public Health Sciences, Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine
- Alan B. Zonderman
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Daniele Cusi
- Institute of Biomedical Technologies, CNR—Italian National Research Council
- Michele K. Evans
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Halina K. Greiser
- Division of Cancer Epidemiology, German Cancer Research Centre
- Pim van der Harst
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Mohammad Hassan
- Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University
- Erik Ingelsson
- Department of Medical Sciences, Molecular Epidemiology, Uppsala University
- Marjo-Riitta Järvelin
- Center for Life Course Health Research, University of Oulu
- Stefan Kääb
- Department of Medicine, University Hospital Munich, Ludwig-Maximilians-University
- Mika Kähönen
- Department of Clinical Physiology, Tampere University Hospital
- Mika Kivimaki
- Department of Epidemiology and Public Health, University College London
- Charles Kooperberg
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Diana Kuh
- MRC Unit for Lifelong Health and Ageing, University College London
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories
- Lars Lind
- Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University
- Caroline M. Nievergelt
- Department of Psychiatry, University of California, San Diego
- Chris J. O'Donnell
- Framingham Heart Study
- Albertine J. Oldehinkel
- Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen
- Brenda Penninx
- Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest
- Alexander P. Reiner
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center
- Harriëtte Riese
- Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen
- Arie M. van Roon
- Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen
- John D. Rioux
- Montreal Heart Institute
- Jerome I. Rotter
- Departments of Pediatrics and Medicine, Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Tamar Sofer
- Department of Biostatistics, School of Public Health, University of Washington
- Bruno H. Stricker
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Henning Tiemeier
- Department of Child and Adolescent Psychiatry/Psychology, Department of Child and Adolescent Psychiatry
- Tanja G. M. Vrijkotte
- Department of Public Health, Academic Medical Center (AMC), University of Amsterdam
- Folkert W. Asselbergs
- Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht
- Bianca J. J. M. Brundel
- Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center
- Susan R. Heckbert
- Department of Medicine, Cardiovascular Health Research Unit, University of Washington
- Eric A. Whitsel
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Marcel den Hoed
- Department of Medical Sciences, Molecular Epidemiology, Uppsala University
- Harold Snieder
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Eco J. C. de Geus
- Department of Biological Psychology, Behavioral and Movement Sciences, VU University
- DOI
- https://doi.org/10.1038/ncomms15805
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Heart rate variability (HRV) describes the individual variation in cardiac cycle duration and is a measure of vagal control of heart rate. Here, the authors identify seventeen single-nucleotide polymorphisms associated with HRV, lending new insight into the vagal regulation of heart rhythm.
