Journal of IMAB (May 2011)

SYNTHESIS OF OLIGOPEPTIDES OF DEFINED FRAGMENT COMPOSITION

  • Tamara Paypanova,
  • Tatyana Hristova,
  • Rumyana Cherkezova

Journal volume & issue
Vol. 17, no. 1
pp. 127 – 129

Abstract

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The advantages of the solid-phase peptide synthesis were used. The peptide chain was built on specially processed insoluble polymer resin: Wang- and Rink Amide MBHA-resin. Three new fragment oligopeptides were prepared by activation and condensation of Fmoc-protected amino acids [which were subject of our previous work]. One of the important advantages of Fmoc-strategy is achieved: no continuous unblocking of the protection group is effected and the formed peptide bonds do not break.

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